Disease-related studies in the fly model
If the goal is human disease-related studies, why do functional genomics in Drosophila?
Flies provide
- a simple, low-redundancy, well-annotated genome
- all major signaling pathways conserved (Hh, Toll, Hippo, etc.)
- best understood model of insect vectors of diseases (e.g. mosquitoes) and insect pests
- proven model of human diseases including cancer, heart disease, obesity and diabetes, neurodegenerative diseases, congenital disorders, kidney stones, neuronal injury, behavioral disorders, and more
Many researchers use our technologies to to uncover new findings relevant to disease and potential drug targets. We welcome inquiries from non-Drosophila researchers looking to connect with specific expertise and resources. We also recommend our fly models of human diseases blog.
Our HuDis-TRiP fly stocks page lists RNAi fly stocks targeting fly orthologs of human disease-associated genes. Learn more about the HuDis-TRiP project at this page.
See links below to relevant online tools, reagents, publications, and more.
News
DRSC/TRiP and DRSC-BTRR Office Hours
New this fall: Online office hours! Do you have questions about modifying Drosophila cell lines with CRISPR or performing large-scale cell screens? Questions about in vivo RNAi with TRiP fly stocks or CRISPR knockout or activation with our sgRNA fly...
New publications from the DRSC bioinformatics team
The DRSC bioinformatics team, led by Dr. Claire Yanhui Hu, has recently published two new papers. One reports development of BioLitMine, an advanced literature mining resource. The other provides an overview of our online resources, which can be grouped...
DRSC-Biomedical Technology Research Resource
We are pleased to announce that we have been funded by NIH NIGMS to form the Drosophila Research & Screening Center-Biomedical Technology Research Resource (DRSC-BTRR). The P41-funded DRSC-BTRR (N. Perrimon, PI; S. Mohr, Co-I) builds upon and extends past...
Drosophila cell screen with DRSC reagent library contributes to identification of new therapeutic target for renal cancer
We here at the DRSC/TRiP are thrilled to see this study from Hilary Nicholson et al. published in Science Signaling. The study provides a great example of how screens in Drosophila cultured cells can be used as part of a cross-species platform aimed at...
DRSC Bioinformatics launches iProteinDB and BioLitMine
We have two new online tools available: iProteinDB and BioLitMine. Both continue our series of resources aimed at integrating existing information in new ways to facilitate data mining and development of new hypotheses. In addition, iProteinDB includes a...
Community Building and Online Resources at the DRSC/TRiP
At the DRSC/TRiP-Functional Genomics Resources, we are interested to let the community know about new resources we have built. We are also interested more broadly to help connect community members to additional resources that could help their research...
Contact Us
Please contact us for any questions.
Publications
2021
Raghuvir Viswanatha, Enzo Mameli, Jonathan Rodiger, Pierre Merckaert, Fabiana Feitosa-Suntheimer, Tonya Colpitts, Stephanie Mohr, Yanhui Hu, and Norbert Perrimon. 2021. “Bioinformatic and Cell-Based Tools for Pooled CRISPR Knockout Screening in Mosquitos”. Nat Commun, 12, 1, Pp. 6825. doi:10.1038/s41467-021-27129-3
Raghuvir Viswanatha, Enzo Mameli, Jonathan Rodiger, Pierre Merckaert, Fabiana Feitosa-Suntheimer, Tonya Colpitts, Stephanie Mohr, Yanhui Hu, and Norbert Perrimon. 2021. “Bioinformatic and Cell-Based Tools for Pooled CRISPR Knockout Screening in Mosquitos”. Nat Commun, 12, 1, Pp. 6825. doi:10.1038/s41467-021-27129-3
Hans M. Dalton, Raghuvir Viswanatha, Ricky Brathwaite Jr., Jae Sophia Zuno, Stephanie Mohr, Norbert Perrimon, and Clement Y. Chow. 2021. “A Genome-Wide CRISPR Screen Identifies the Glycosylation Enzyme DPM1 As a Modifier of DPAGT1 Deficiency and ER Stress”. BioRxiv
Hans M. Dalton, Raghuvir Viswanatha, Ricky Brathwaite Jr., Jae Sophia Zuno, Stephanie Mohr, Norbert Perrimon, and Clement Y. Chow. 2021. “A Genome-Wide CRISPR Screen Identifies the Glycosylation Enzyme DPM1 As a Modifier of DPAGT1 Deficiency and ER Stress”. BioRxiv
2020
Yanhui Hu, Verena Chung, Aram Comjean, Jonathan Rodiger, Fnu Nipun, Norbert Perrimon, and Stephanie Mohr. 2020. “BioLitMine: Advanced Mining of Biomedical and Biological Literature About Human Genes and Genes from Major Model Organisms”. G3 (Bethesda). doi:10.1534/g3.120.401775
Yanhui Hu, Verena Chung, Aram Comjean, Jonathan Rodiger, Fnu Nipun, Norbert Perrimon, and Stephanie Mohr. 2020. “BioLitMine: Advanced Mining of Biomedical and Biological Literature About Human Genes and Genes from Major Model Organisms”. G3 (Bethesda). doi:10.1534/g3.120.401775
Yanhui Hu, Aram Comjean, Jonathan Rodiger, Yifang Liu, Yue Gao, Verena Chung, Jonathan Zirin, Norbert Perrimon, and Stephanie Mohr. 2020. “FlyRNAi.Org-the Database of the Drosophila RNAi Screening Center and Transgenic RNAi Project: 2021 Update”. Nucleic Acids Res. doi:10.1093/nar/gkaa936
Yanhui Hu, Aram Comjean, Jonathan Rodiger, Yifang Liu, Yue Gao, Verena Chung, Jonathan Zirin, Norbert Perrimon, and Stephanie Mohr. 2020. “FlyRNAi.Org-the Database of the Drosophila RNAi Screening Center and Transgenic RNAi Project: 2021 Update”. Nucleic Acids Res. doi:10.1093/nar/gkaa936
2019
Andrey Parkhitko, Patrick Jouandin, Stephanie Mohr, and Norbert Perrimon. 2019. “Methionine Metabolism and Methyltransferases in the Regulation of Aging and Lifespan Extension across Species”. Aging Cell, Pp. e13034. doi:10.1111/acel.13034
Andrey Parkhitko, Patrick Jouandin, Stephanie Mohr, and Norbert Perrimon. 2019. “Methionine Metabolism and Methyltransferases in the Regulation of Aging and Lifespan Extension across Species”. Aging Cell, Pp. e13034. doi:10.1111/acel.13034
Stephanie E. Mohr and Norbert Perrimon. 2019. “Drosophila Melanogaster: A Simple System for Understanding Complexity.”. Dis Model Mech, 12, 10
Stephanie E. Mohr and Norbert Perrimon. 2019. “Drosophila Melanogaster: A Simple System for Understanding Complexity.”. Dis Model Mech, 12, 10