Upcoming Events

More Events

Recent News

Photo of 384-well assay plates

Congrats to Sung, Shears, and colleagues: "Cytokine signaling through Drosophila Mthl10 ties lifespan to environmental stress"

December 13, 2017

Eui Jae Sung, Stephen Shears, and colleagues have published a research report that includes a screen of dsRNAs from the DRSC reagent collection using S2 cells. We shipped dsRNA reagents to the lab for a screen at their home institution, in addition to providing consultation and data management support. The resulting study by Sung et al. was published on Dec. 11, 2017: Sung EJ, Ryuda M, Matsumoto H, Uryu O, Ochiai M, Cook ME, Yi NY, Wang H, Putney JW, Bird GS, Shears SB, Hayakawa Y. Cytokine signaling through Drosophila Mthl10 ties lifespan to environmental stress...

Read more about Congrats to Sung, Shears, and colleagues: "Cytokine signaling through Drosophila Mthl10 ties lifespan to environmental stress"
Figure 2 from Housden et al 2017 PNAS

Variable Dose Analysis: a new DRSC-supported cell screen approach that leverages existing reagents to perform robust screens

December 1, 2017

We are excited to report the publication of a paper from Benjamin Housden and colleagues describing development and use of the Variable Dose Analysis (VDA) approach. Ben developed a way to use existing TRiP shRNA plasmids originally developed for fly stock production in a new, effective approach to high-throughput cell screening.

The VDA approach is particularly useful for combinatorial approaches that are acutely sensitive to assay robustness. The screen Ben and colleagues report focused on synthetic effects in Drosophila tumor model cells. ...

Read more about Variable Dose Analysis: a new DRSC-supported cell screen approach that leverages existing reagents to perform robust screens
More