News

Graphical image of tissue culture, fly pushing, and computer, and the team of people who work with them

DRSC/TRiP and DRSC-BTRR Office Hours

September 13, 2021

New this fall: Online office hours!

Do you have questions about modifying Drosophila cell lines with CRISPR or performing large-scale cell screens? Questions about in vivo RNAi with TRiP fly stocks or CRISPR knockout or activation with our sgRNA fly stocks? Questions about our new protocols and resources for CRISPR mosquito cell lines? Pop into our Zoom office hours to say hello and get our expert input! Registration is required (see below).

DRSC/TRiP & DRSC-BTRR Office Hours Schedule:

Mon. Sept. 27, 2021, 12...

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Image of an anesthetized male Drosophila fruit fly

DRSC/TRiP presentations from June 2020 Boston Area Drosophila Meeting

June 12, 2020
Did you miss the presentations from Claire Hu and Jonathan Zirin at the June 2020 Boston Area Drosophila Meeting? No problem! The slides can be accessed from this post. Click the title above to view the whole post, then scroll down to access the PDFs. These presentations describe what's new and next in bioinformatics and in vivo technologies at the DRSC/TRiP. Feel free to reach out with questions. Interested in the BAD meeting? Info about the meeting can be found here. Read more about DRSC/TRiP presentations from June 2020 Boston Area Drosophila Meeting
from Figure 1 in Ewen-Campen et al. in Dev Cell

Transgenic Fly Stocks for Double Knockout of Paralog Pairs

May 18, 2020

Paralogs can be defined as related genes within a genome that are thought to arise from gene duplication events. Because paralogous proteins share amino acid identity, they can have redundant functions. But the picture is not necessarily so straightforward. Indeed, there are examples in which paralogous genes have distinct functions in some tissues, and overlapping functions in others.

The DRSC/TRiP is engaged in a project in collaboration with the Perrimon and Bellen labs to generate resources useful for the study of paralogous genes in Drosophila.

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Shut-down in response to COVID-19

March 15, 2020

In adherance with Harvard Medical School's response to the COVID-19 pandemic, the DRSC/TRiP-FGR and DRSC-BTRR will be closing our doors by 5 pm on Wed. March 16.

Services will be unavailable for at least 6-8 weeks but leaders and staff will be reachable by email, and related resources are available at the BDSC and DGRC in Indiana, and at Addgene, and information remains available at this site.

We are focused right now on minimizing the impact of the shut-down on our activities. In the future, we expect to be able to make use of the time to help our research...

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Screenshot of the FlyScape tool

Wilinski and colleagues release "FlyScape" for metabolic network visualization

November 7, 2019

The DRSC congratulates Wilinski et al. at the University of Michigan for their release and publication of FlyScape, a tool for metabolic network visualization.

Rapid metabolic shifts occur during the transition between hunger and satiety in Drosophila melanogaster

Daniel Wilinski, Jasmine Winzeler, William Duren, Jenna L. Persons, Kristina J. Holme, Johan Mosquera, Morteza Khabiri, Jason M. Kinchen, Peter L. Freddolino, Alla Karnovsky & Monica Dus 

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Graphical image of tissue culture, fly pushing, and computer, and the team of people who work with them

DRSC-Biomedical Technology Research Resource

October 21, 2019

We are pleased to announce that we have been funded by NIH NIGMS to form the Drosophila Research & Screening Center-Biomedical Technology Research Resource (DRSC-BTRR). The P41-funded DRSC-BTRR (N. Perrimon, PI; S. Mohr, Co-I) builds upon and extends past goals of the Drosophila RNAi Screening Center.

As the DRSC-BTRR, we are working together with collaborators whose 'driving biomedical projects' inform development of new technologies at the DRSC. At the same time, we continue to support Drosophila cell-based RNAi and CRIPSR knockout screens and related...

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Photo of 384-well assay plates

Drosophila cell screen with DRSC reagent library contributes to identification of new therapeutic target for renal cancer

October 7, 2019

We here at the DRSC/TRiP are thrilled to see this study from Hilary Nicholson et al. published in Science Signaling.

The study provides a great example of how screens in Drosophila cultured cells can be used as part of a cross-species platform aimed at discovery of new targets for disease treatment. The work represents a collaboration between the laboratory of 2019 Nobel Prize winner W. Kaelin and DRSC PI N. Perrimon.

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