News

Nanobodies against NanoTags now easier to access

July 22, 2026

The nanobodies recognizing the VHH05-tag and 127D01-tag, two short epitope tags developed by our group for use in Drosophila , are now available in purified form from Cell Signaling Technology (CST). These "NanoTags" and their corresponding high-affinity...

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DIOPT online ortholog search tool updated

January 07, 2026

We recently updated our DIOPT online ortholog search tool. Notable changes include addition of predictions for the black-legged tick, Ixodes scapularis, and removal of an outdated ortholog prediction set. Please see the attached PDF for a visual summary...

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PANGEA online tool updated

January 07, 2026

We recently updated our PANGEA gene set enrichment analysis tool. The tool now supports gene set enrichment analysis for the malaria mosquito Anopheles gambiae and the black-legged tick Ixodes scapularis. In addition, we have added new gene sets for gene...

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Video featuring in vivo projects and highlighting ways to connect with our group

June 20, 2024

We made a (very short) movie! Learn about some of our in vivo projects and ways to collaborate with our group. Click below to start the 2-minute movie playing in your browser window: cmrdm_drsc_final.mp4

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New cell lines & new understandings using cutting-edge techniques

February 02, 2024

As a facility that supports large-scale screens in Drosophila and other insect cell lines, we get excited about reports of new Drosophila cell lines and related info. We'd like to highlight two recent papers. One report, a collaboration between Amanda...

Light up your flies! Reagent and protocol information for application of our NanoTag system for epitope tagging in Drosophila

March 23, 2023

One of the areas of interest for our technology development group is nanobodies. These small, single-chain antibodies are particularly attractive for Drosophila research as in addition to being used for standard immune-technologies such as immunoblots and...

Important new considerations for TRiP stock users

August 29, 2022

A handful of recent papers and preprints have highlighted some important considerations for using TRiP shRNA and sgRNA stocks. First, the Weake lab at Purdue University discovered that TRiP stocks contain a previously uncharacterized loss-of-function...

So you want to do a CRISPR pooled screen in insect cells? You can! Here's how

May 12, 2022

At the DRSC-BTRR, we've been doing a lot of pooled-format CRISPR knockout screens in Drosophila cells. We're finding the results to be robust and reproducible. And best of all, the results have been informative, providing insights into diverse areas of...

Read the DRSC/TRiP Report to the Fly Board 2022

March 31, 2022

Below we share with the community at large the report we provided to the Fly Board in advance of the 2022 Fly Meeting. As always, your feedback on our technologies and services is welcome. We are here to help. DRSC/TRiP Functional Genomics Resources at...

DRSC/TRiP and DRSC-BTRR Office Hours

September 13, 2021

New this fall: Online office hours! Do you have questions about modifying Drosophila cell lines with CRISPR or performing large-scale cell screens? Questions about in vivo RNAi with TRiP fly stocks or CRISPR knockout or activation with our sgRNA fly...

New from the DRSC and Perrimon lab: DRscDB resource for mining of single-cell data sets

February 01, 2021

We are excited to launch our DRscDB online resource for mining of single-cell RNAseq data sets from Drosophila and other species. You can read more about the resource in our BioRxiv preprint.

New publications from the DRSC bioinformatics team

October 28, 2020

The DRSC bioinformatics team, led by Dr. Claire Yanhui Hu, has recently published two new papers. One reports development of BioLitMine, an advanced literature mining resource. The other provides an overview of our online resources, which can be grouped...