News

Screenshot of a 2015 Science paper from Payre and colleagues

Francois Payre's plenary talk at ADRC 2017 features results from DRSC cell-based screen

March 30, 2017

Those of us lucky enough to be at the Annual Drosophila Research Conference this morning saw a great talk by Francois Payre about regulation of Shavenbaby by small ORFs. A genome-wide cell-based screen done at the DRSC by Emilie Benrabah identified the mechanism of regulation. As this exemplifies, cell screens can help identify key pathways and factors that can then be followed up with in vivo studies.

New stocks added to the TRiP in vivo RNAi library

January 6, 2017

The TRiP has updated and curated our list of in vivo RNAi reagents for gene knockdown in fruitflies. To date, we have produced over 13,000 stocks for the benefit of the scientific community.

Visit the in vivo RNAi fly stocks and vectors page to download an excel file with the full list of fly stocks now available for order from the Bloomington Drosophila Stock Center (BDSC) and the

Read more about New stocks added to the TRiP in vivo RNAi library

CRISPR sgRNA design tool now based on Drosophila genome assembly 6

December 21, 2016

We have updated our CRISPR sgRNA design tool. The results and JBrowse display are now based on Drosophila melanogaster FlyBase genome assembly release 6. We have also added seed scores in addition to efficiency prediction scores and other values available on detailed views of sgRNA designs. Quick tips: start a search with a gene symbol or other identifier, use the

Read more about CRISPR sgRNA design tool now based on Drosophila genome assembly 6
Amino acid alignment of the fly paralogs kek1 and kek2

DIOPT 6.0 released -- with eggNOG and paralog searches added

November 29, 2016

DIOPT 6.0 went live this week. Newly added features include results from eggNOG, bringing the total number of alrogithms incorporated in our integrated search tool to 14. In addition, you can now search for paralogs. To do this, choose the same species for input and output. Examples for fly-fly and human-human paralog searches are shown. As always, your feedback is welcome.

Read more about DIOPT 6.0 released -- with eggNOG and paralog searches added
Screenshot of GLAD results with the hh gene

Gene List Annotation for Drosophila (GLAD) online resource updated

October 19, 2016

We recently udpated our Gene List Annotation for Drosophila (GLAD) online resource.  At GLAD you could already view the members of a gene list, such as genes grouped as members of a pathway, process, or sharing a functional domain. Now, you can also ask if a gene of interest is a member of a given group. Please see examples of the two ways to use GLAD below. As always, we welcome your feedback, including suggestions for changes or additions to the curated lists, or for addition of new

Read more about Gene List Annotation for Drosophila (GLAD) online resource updated
Multi sequence alignments for ALL search best matches

"One vs. All" a new feature in our ortholog search tool

October 3, 2016

Our DIOPT ortholog search tool has been updated to include the option to search for orthologs of a gene in all other species included. So you can search with, for example, a fly gene, and see orthologs in human, mouse, rat, frog, worm, and yeast.

Click on the button "show summary of top scores" to see a heat map view of the top-scoring ortholog matches in other species to your query species. This feature helps you see quickly if a gene has been conserved across many species or is, for example, only found in vertebrates.

As always, our tool supports batch-mode searches (you can

Read more about "One vs. All" a new feature in our ortholog search tool