The DRSC bioinformatics team, led by Dr. Claire Yanhui Hu, has recently published two new papers.
One reports development of BioLitMine, an advanced literature mining resource. The other provides an overview of our online resources, which can be grouped into reagent, gene, and data-focused resources.
Did you miss the presentations from Claire Hu and Jonathan Zirin at the June 2020 Boston Area Drosophila Meeting? No problem! The slides can be accessed from this post. Click the title above to view the whole post, then scroll down to access the PDFs. These presentations describe what's new and next in bioinformatics and in vivo technologies at the DRSC/TRiP. Feel free to reach out with questions. Interested in the BAD meeting? Info about the meeting can be found here. Read more about DRSC/TRiP presentations from June 2020 Boston Area Drosophila Meeting
Paralogs can be defined as related genes within a genome that are thought to arise from gene duplication events. Because paralogous proteins share amino acid identity, they can have redundant functions. But the picture is not necessarily so straightforward. Indeed, there are examples in which paralogous genes have distinct functions in some tissues, and overlapping functions in others.
The DRSC/TRiP is engaged in a project in collaboration with the Perrimon and Bellen labs to generate resources useful for the study of paralogous genes in Drosophila.
In adherance with Harvard Medical School's response to the COVID-19 pandemic, the DRSC/TRiP-FGR and DRSC-BTRR will be closing our doors by 5 pm on Wed. March 16.
Services will be unavailable for at least 6-8 weeks but leaders and staff will be reachable by email, and related resources are available at the BDSC and DGRC in Indiana, and at Addgene, and information remains available at this site.
We are focused right now on minimizing the impact of the shut-down on our activities. In the future, we expect to be able to make use of the time to help our research...
Learn about DRSC/TRiP activities focused on using CRISPR activation to develop human disease models in a recently published Q&A with our Director, Dr. S.E. Mohr, who will be a speaker this spring at an upcoming genome editing conference in Boston, MA.
We are pleased to announce that we have been funded by NIH NIGMS to form the Drosophila Research & Screening Center-Biomedical Technology Research Resource (DRSC-BTRR). The P41-funded DRSC-BTRR (N. Perrimon, PI; S. Mohr, Co-I) builds upon and extends past goals of the Drosophila RNAi Screening Center.
As the DRSC-BTRR, we are working together with collaborators whose 'driving biomedical projects' inform development of new technologies at the DRSC. At the same time, we continue to support Drosophila cell-based RNAi and CRIPSR knockout screens and related...
We here at the DRSC/TRiP are thrilled to see this study from Hilary Nicholson et al. published in Science Signaling.
The study provides a great example of how screens in Drosophila cultured cells can be used as part of a cross-species platform aimed at discovery of new targets for disease treatment. The work represents a collaboration between the laboratory of 2019 Nobel Prize winner W. Kaelin and DRSC PI N. Perrimon.
Users of TRiP RNAi and sgRNA fly stocks take note: the Weake lab at Purdue University brought to our attention that some TRiP fly stocks carry a mutant allele of seveneless. Jonathan Zirin worked with Spencer Escobedo and Vikki Weake, as well as with folks at the Bloomington Drosophila Stock Center, to quickly identify the source, sequence the mutant allele, and pubilsh a micropublication so we can get the details to the community. Bottom line, as stated in the micropublication, "The presence of the sev mutation will not generally affect the use of these stocks, as the X...
We have been taking a critical look at how we organize our online tools on the Online Tools Overview page. And more generally, we have been thinking about new ways to spread the word about the many resources in our suite of online tools. One way that we at the DRSC like to think about these tools is how they fit into the start-to-finish order of events in a screen or other experimental project. Various tools help define lists of genes to be studied, help identify reagents for the study,...