News

Missed us at ADRC 2018? View our workshop slides!

April 19, 2018

Thank you to all those who attended our workshop at last week's Annual Drosophila Research Conference in Philadelphia, PA, USA. It was great to talk fly stocks, cell screens, and bioinformatics with the community. We are here to help and look forward to...

Pooled-format CRISPR screens in Drosophila cells

March 22, 2018

The DRSC/TRiP-FGR is pleased to support collaborations on pooled CRISPR screens using the method recently, reported in eLife by Viswanatha et al. (PDF download file below). From the abstract: "... Here, we developed a site-specific integration strategy...

We're hiring at the research assistant level

February 19, 2018

We are looking for strong candidates for a research assistant position at the DRSC/TRiP Functional Genomics Resources. Be sure to note in your resume if you have experience with Drosophila genetics or cell culture. Details and information about how to...

Congrats to Sung, Shears, and colleagues: "Cytokine signaling through Drosophila Mthl10 ties lifespan to environmental stress"

December 13, 2017

Eui Jae Sung, Stephen Shears, and colleagues have published a research report that includes a screen of dsRNAs from the DRSC reagent collection using S2 cells. We shipped dsRNA reagents to the lab for a screen at their home institution, in addition to...

Variable Dose Analysis: a new DRSC-supported cell screen approach that leverages existing reagents to perform robust screens

December 01, 2017

We are excited to report the publication of a paper from Benjamin Housden and colleagues describing development and use of the Variable Dose Analysis (VDA) approach. Ben developed a way to use existing TRiP shRNA plasmids originally developed for fly...

Tutorial on DIOPT ortholog search tool scores, ranks and 'best' matches

October 10, 2017

In response to a request placed using our bug report form, we have put together a YouTube video demonstration that explains the scores, ranks, and 'best' matches that appear as part of the results tables at the DRSC Integrative Ortholog Precition Tool or...

TRiP-CRISPR stocks now available at BDSC

September 15, 2017

TRiP-CRISPR stocks are now being distributed via the Bloomington Drosophila Stock Center (BDSC). You can find the list of guide RNA stocks for gene knockout or overexpression through the guideRNAs link on the BDSC homepage. The TRiP-CRISPR Toolbox of Gal4...

Nucleolar image-based screen dataset viewable online with OMERO

August 01, 2017

The DRSC has worked with the HMS Image Data Management Core to make a ~3 TB image fluorescence confocal screen image dataset from the screen reported in Neumuller et al. available online. And not just available--with several interaction options! At the...

Plasmid clones and data available from the FlyBi project

June 08, 2017

The DRSC is collaborating with the Berkeley Drosophila Genome Project and the DFCI Center for Cancer Systems Biology on a large-scale Drosophila binary protein interaction project, the FlyBi project. We have deposited Drosophila ORFs in Gateway vectors at...

The TRiP is now taking nominations for CRISPR stocks

May 12, 2017

The TRiP is excited to announce our new TRiP-CRISPR transgenic fly libraries for gene knockout and overexpression. Visit the sgRNA tracking site to download and search existing TRiP-CRISPR fly stocks by gene or stock ID to obtain information on sgRNA...

Francois Payre's plenary talk at ADRC 2017 features results from DRSC cell-based screen

March 30, 2017

Those of us lucky enough to be at the Annual Drosophila Research Conference this morning saw a great talk by Francois Payre about regulation of Shavenbaby by small ORFs. A genome-wide cell-based screen done at the DRSC by Emilie Benrabah identified the...

New automated imaging at the DRSC

January 27, 2017

The DRSC/TRiP-FGR is pleased to announce that we recently updated our high-throughput, high-content imaging system. Through funds from NIH, HHMI, and the Harvard Medical School Tools & Technology program, we were able to get a GE IN Cell 6000 automated...