News & Events

News

New stocks added to the TRiP in vivo RNAi library

January 6, 2017

The TRiP has updated and curated our list of in vivo RNAi reagents for gene knockdown in fruitflies. To date, we have produced over 13,000 stocks for the benefit of the scientific community.

Visit the in vivo RNAi fly stocks and vectors page to download an excel file with the full list of fly stocks now available for order from the Bloomington Drosophila Stock Center (BDSC) and the National Institute of Genetics, Japan (NIG-Fly).

 

Amino acid alignment of the fly paralogs kek1 and kek2

DIOPT 6.0 released -- with eggNOG and paralog searches added

November 29, 2016

DIOPT 6.0 went live this week. Newly added features include results from eggNOG, bringing the total number of alrogithms incorporated in our integrated search tool to 14. In addition, you can now search for paralogs. To do this, choose the same species for input and output. Examples for fly-fly and human-human paralog searches are shown. As always, your feedback is welcome.

Screenshot of GLAD results with the hh gene

Gene List Annotation for Drosophila (GLAD) online resource updated

October 19, 2016

We recently udpated our Gene List Annotation for Drosophila (GLAD) online resource.  At GLAD you could already view the members of a gene list, such as genes grouped as members of a pathway, process, or sharing a functional domain. Now, you can also ask if a gene of interest is a member of a given group. Please see examples of the two ways to use GLAD below. As always, we welcome your feedback, including suggestions for changes or additions to the curated lists, or for addition of new lists.

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Events

2017 May 10

Presentation at Genome Editing and Trangenic Congress USA

10:00am

Location: 

Boston, MA

Stephanie will be presenting at the Genome Editing and Transgenic Congress USA in Boston, MA, on May 10, 2017 (time TBD). She plans to cover the following topics.

  • Strategy and results of optimization of Cas9 fusion proteins for CRISPR activation in cells and in vivo
  • Genome-scale design of single guide RNAs (sgRNAs) for CRISPR activation
  • Use of CRISPR activation in Drosophila for large-scale gene function discovery and disease modeling
2017 Mar 29

DRSC & TRiP at ADRC 2017

Mar 29 (All day) to Apr 02 (All day)

Location: 

San Diego, CA

The DRSC & TRiP will be at the Annual Drosophila Research Conference (aka 'the fly meeting') in San Diego, CA, in March/April of 2017. Please feel free to contact us if you'd like to set up a meeting to discuss a screen project or other research need we can help with.

2016 Dec 01

Harvard Med School Research Core Facilities Showcase

3:30pm to 5:30pm

Location: 

TMEC Atrium on the Harvard Medical School campus

The DRSC & TRiP will be represented at the HMS Research Cores Showcase. The event will be comprised of a poster session and reception. The event provides an opportunity for HMS students, postdocs, and faculty can get to know what offerings are available from facilities on the campus. If you are local to HMS, drop by to say hello or ask questions about our offerings in the area of cell-based screening, RNAi and CRISPR fly stocks, and bioinformatics.

2016 Sep 28

Functional genomics techniques in Drosophila and their potential application in non-model insects

11:45am to 12:00pm

Location: 

Orlando, FL

DRSC-FGR Director S. Mohr will be presenting in the symposium Insect Genetic Technologies: State of the Art and Promise for the Future at the International Congress of Entomology (ICE 2016). Come hear what is possible in Drosophila that might be applied to other insect species. Wednesday, September 28, 2016 at 11:45 am (symposium from 9:30 - 12:30).

2016 Sep 23

Boston Area Drosophila Meeting

1:00pm to 4:30pm

Location: 

University of Massachusetts Boston

The DRSC-Functional Genomics Resources (formerly DRSC & TRiP) will be participating in the Boston Area Drosophila Meeting, which was organized by Alexey Verakas of UMass Boston and Jim Walker of Harvard Medical School. Hear about what's new in technologies and online tools at this regional meeting of experts in Drosophila research.

2016 Jul 16

Functional Genomics for Conserved Gene Function Discovery (TAGC 2016)

8:00am to 10:00am

Location: 

Orlando, FL

Functional genomics permits gene function discovery at large scale. The power of the approach increases when related genes in multiple species are shown to have similar functions. We bring together experts in functional genomics in single-cell, invertebrate and vertebrate models to present their effective platforms, with an emphasis on cross-species studies (e.g. parallel screens in multiple species or screens in one system followed up in another).