News & Events

News

Photo of 384-well assay plates

Congrats to Sung, Shears, and colleagues: "Cytokine signaling through Drosophila Mthl10 ties lifespan to environmental stress"

December 13, 2017

Eui Jae Sung, Stephen Shears, and colleagues have published a research report that includes a screen of dsRNAs from the DRSC reagent collection using S2 cells. We shipped dsRNA reagents to the lab for a screen at their home institution, in addition to providing consultation and data management support. The resulting study by Sung et al. was published on Dec. 11, 2017: Sung EJ, Ryuda M, Matsumoto H, Uryu O, Ochiai M, Cook ME, Yi NY, Wang H, Putney JW, Bird GS, Shears SB, Hayakawa Y. Cytokine signaling through Drosophila Mthl10 ties lifespan to environmental stress...

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Figure 2 from Housden et al 2017 PNAS

Variable Dose Analysis: a new DRSC-supported cell screen approach that leverages existing reagents to perform robust screens

December 1, 2017

We are excited to report the publication of a paper from Benjamin Housden and colleagues describing development and use of the Variable Dose Analysis (VDA) approach. Ben developed a way to use existing TRiP shRNA plasmids originally developed for fly stock production in a new, effective approach to high-throughput cell screening.

The VDA approach is particularly useful for combinatorial approaches that are acutely sensitive to assay robustness. The screen Ben and colleagues report focused on synthetic effects in Drosophila tumor model cells. ...

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Events

2018 Apr 13

DRSC & TRiP Workshop at ADRC

1:45pm to 3:45pm

Location: 

Philadelphia, PA, USA
The DRSC & TRiP will be hosting a workshop at the Annual Drosophila Research Conference in Philadelphia, PA. The workshop is scheduled for Friday, April 13th from 1:45 to 3:45 PM. Come hear from DRSC & TRiP leaders Norbert Perrimon, Jonathan Zirin (organizer), Claire Yanhui Hu, and Stephanie Mohr. At the workshop, you will learn about new opportunities for community nomination and experiments using CRISPR knockout and activation, as well as learn what's new and popular among our online software and database tools. There will be something for everyone -- we will provide information... Read more about DRSC & TRiP Workshop at ADRC
2018 Apr 11

59th Annual Drosophila Research Conference

Wed Apr 11 (All day) to Sun Apr 15 (All day)

Location: 

Philadelphia, PA, USA
The DRSC & TRiP leadership consider the Annual Drosophila Research Conference the 'must-go' conference of the year. We use ADRC meetings as an opportunity to update the community on existing and new services, reagent collections, and online tools, as well as for one-on-one consults with researchers planning high-throughput screens. The next ADRC is scheduled for April 11-15. 2018, in Philadelphia, PA, USA. Feel free to contact us if you'll also be there and would... Read more about 59th Annual Drosophila Research Conference
2017 Oct 12

DRSC attendance at the Genomics Discovery Initiative Annual Meeting 2017

(All day)

Location: 

Philadelphia, PA
The DRSC leadership will be participating in the Genomics Discovery Initiative annual meeting 2017, which is hosted by GE Healthcare Dharmacon. We look forward to conneting with and learning from colleagues in academia and industry represented at the meeting. Events on Friday, Oct. 13, 2017, are open to the public.
2017 Sep 25

Presentation on "High-throughput CRISPR-based approaches to cancer target identification" at CHI Discovery on Target in Boston, MA

Mon Sep 25 (All day) to Fri Sep 29 (All day)

Location: 

Boston, MA, USA

On Sept. 27, 2017, DRSC/TRiP-FGR Director S. Mohr will present a talk on "High-throughput CRISPR-based approaches to cancer target identification," part of the inaugural Target Identification Strategies session at the 1th annual CHI Discovery on Target conference at the Westin Copley Place, Boston, MA, USA...

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2017 May 10

Presentation at Genome Editing and Trangenic Congress USA

10:00am

Location: 

Boston, MA

Stephanie will be presenting at the Genome Editing and Transgenic Congress USA in Boston, MA, on May 10, 2017 (time TBD). She plans to cover the following topics.

  • Strategy and results of optimization of Cas9 fusion proteins for CRISPR activation in cells and in vivo
  • Genome-scale design of single guide RNAs (sgRNAs) for CRISPR activation
  • Use of CRISPR activation in Drosophila for large-scale gene function discovery and disease modeling
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