DRSC-BTRR Driving Biomedical Projects

The goal of DRSC-BTRR Driving Biomedical Projects (DBPs) is to partner our technology development efforts with unmet needs in the community. Collabortors engage with us in the technology development process and provide critical feedback, feeding an iterative cycle of technology development and improvement. Please feel free to contact the DRSC-BTRR Director S.E. Mohr to discuss potential new collaborations.

The DRSC-BTRR is engaged in the following DBPs
(last udpated Feb. 2021)

H. Bellen, Baylor College of Medicine, “Use of Drosophila cultured cells as a test system for optimization of new MiMIC system CRISPR knock-in approaches and cassettes.”

S. Cherry, Univ. of Pennsylvania, “Use of CRISPR pooled screens in Drosophila cells to identify the mechanisms of action of drugs.”

T. Colpitts, Boston University & National Emerging Infectious Diseases Laboratory (NEIDL), “Establishing assays relevant to infection of mosquito cells by viral pathogens, for mosquito CRISPR pooled cell screening.”

C. Chow, University of Utah, “Drosophila CRISPR pooled cell screens to explore cell biological topics related to rare diseases.”

G. Dimopoulous, Johns Hopkins, “Identification of candidate protein binders of mosquito proteins.”

M. Dong, Boston Children’s Hospital, “Genome-wide CRISPR/Cas9 screen to identify the receptors for insecticidal toxins.”

F. Douam, Boston University and NEIDL. “Establishing assays relevant to infection of mosquito cells by viral pathogens, for mosquito CRISPR pooled cell screening.”

S. Kadener, Brandeis University, “Adapting the RNA-targeting Cas13 system for use in vivo in Drosophila to study circular RNAs.” Resulted reported in BioRxiv (Viswanatha et al. 2020)

V. Gantz, UCSD, “Use of Culex cell lines as a testing platform for CRISPR-Cas9 optimization for eventual use in gene drive applications in vivo.”

W. Kaelin, Dana Farber Cancer Institute, “Cross-species, functional genomics screening to identify synthetic lethal interactors with tumor suppressor genes.”

R. Lehmann, Whitehead Institute/MIT, “Identification of protein binders for the study of Wolbachia in Drosophila.”

N. Lao, Boston University, “Use of pooled CRISPR screens in mosquito cell lines to identify genes relevant to piRNAs.”

R. Smith, Iowa State University, “Pooled CRISPR screening in Anopheles cell lines to investigate cell biological activities.”

K. Zinn, Caltech, “Identification of protein binders of DIP and Dpr family proteins.”

Preprints and publications resulting from DRSC-BTRR DBPs