PMID- 37933691
OWN - NLM
STAT- Publisher
LR  - 20231107
IS  - 1943-2631 (Electronic)
IS  - 0016-6731 (Linking)
DP  - 2023 Nov 2
TI  - Finding information about uncharacterized Drosophila melanogaster genes.
LID - iyad187 [pii]
LID - 10.1093/genetics/iyad187 [doi]
AB  - Genes that have been identified in the genome but remain uncharacterized with 
      regards to function offer an opportunity to uncover novel biological information. 
      Novelty is exciting but can also be a barrier. If nothing is known, how does one 
      start planning and executing experiments? Here, we provide a recommended 
      information-mining workflow and a corresponding guide to accessing information 
      about uncharacterized Drosophila melanogaster genes, such as those assigned only 
      a systematic coding gene identifier. The available information can provide 
      insights into where and when the gene is expressed, what the function of the gene 
      might be, whether there are similar genes in other species, whether there are 
      known relationships to other genes, and whether any other features have already 
      been determined. In addition, available information about relevant reagents can 
      inspire and facilitate experimental studies. Altogether, mining available 
      information can help prioritize genes for further study, as well as provide 
      starting points for experimental assays and other analyses.
CI  - © The Author(s) 2023. Published by Oxford University Press on behalf of The 
      Genetics Society of America. All rights reserved. For permissions, please e-mail: 
      journals.permissions@oup.com.
FAU - Mohr, Stephanie E
AU  - Mohr SE
AUID- ORCID: 0000-0001-9639-7708
AD  - Department of Genetics, Blavatnik Institute, Harvard Medical School, 77 Avenue 
      Louis Pasteur, Boston, MA 02115, USA.
FAU - Kim, Ah-Ram
AU  - Kim AR
AD  - Department of Genetics, Blavatnik Institute, Harvard Medical School, 77 Avenue 
      Louis Pasteur, Boston, MA 02115, USA.
FAU - Hu, Yanhui
AU  - Hu Y
AUID- ORCID: 0000-0003-1494-1402
AD  - Department of Genetics, Blavatnik Institute, Harvard Medical School, 77 Avenue 
      Louis Pasteur, Boston, MA 02115, USA.
FAU - Perrimon, Norbert
AU  - Perrimon N
AD  - Department of Genetics, Blavatnik Institute, Harvard Medical School, 77 Avenue 
      Louis Pasteur, Boston, MA 02115, USA.
AD  - Howard Hughes Medical Institute, Boston, MA 02115, USA.
LA  - eng
GR  - HHMI/Howard Hughes Medical Institute/United States
PT  - Journal Article
DEP - 20231102
PL  - United States
TA  - Genetics
JT  - Genetics
JID - 0374636
SB  - IM
OTO - NOTNLM
OT  - Drosophila
OT  - data curation
OT  - databases
OT  - information mining
OT  - knowledgebases
OT  - novel genes
OT  - uncharacterized genes
COIS- Conflicts of interest statement The author(s) declare no conflict of interest.
EDAT- 2023/11/07 12:45
MHDA- 2023/11/07 12:45
CRDT- 2023/11/07 06:42
PHST- 2023/11/07 12:45 [medline]
PHST- 2023/11/07 12:45 [pubmed]
PHST- 2023/07/31 00:00 [received]
PHST- 2023/10/02 00:00 [accepted]
PHST- 2023/11/07 06:42 [entrez]
AID - 7337046 [pii]
AID - 10.1093/genetics/iyad187 [doi]
PST - aheadofprint
SO  - Genetics. 2023 Nov 2:iyad187. doi: 10.1093/genetics/iyad187.