%0 Journal Article %J Nucleic Acids Res %D 2006 %T FlyRNAi: the Drosophila RNAi screening center database. %A Flockhart, Ian %A Booker, Matthew %A Kiger, Amy %A Boutros, Michael %A Armknecht, Susan %A Ramadan, Nadire %A Richardson, Kris %A Xu, Andrew %A Perrimon, Norbert %A Mathey-Prevot, Bernard %K Animals %K Computational Biology %K Databases, Genetic %K Drosophila %K Gene Library %K Genome, Insect %K Internet %K RNA Interference %K RNA, Double-Stranded %K Software %K User-Computer Interface %X

RNA interference (RNAi) has become a powerful tool for genetic screening in Drosophila. At the Drosophila RNAi Screening Center (DRSC), we are using a library of over 21,000 double-stranded RNAs targeting known and predicted genes in Drosophila. This library is available for the use of visiting scientists wishing to perform full-genome RNAi screens. The data generated from these screens are collected in the DRSC database (http://flyRNAi.org/cgi-bin/RNAi_screens.pl) in a flexible format for the convenience of the scientist and for archiving data. The long-term goal of this database is to provide annotations for as many of the uncharacterized genes in Drosophila as possible. Data from published screens are available to the public through a highly configurable interface that allows detailed examination of the data and provides access to a number of other databases and bioinformatics tools.

%B Nucleic Acids Res %V 34 %P D489-94 %8 2006 Jan 1 %G eng %N Database issue %1 http://www.ncbi.nlm.nih.gov/pubmed/16381918?dopt=Abstract %R 10.1093/nar/gkj114