TY - JOUR T1 - FlyRNAi: the Drosophila RNAi screening center database. JF - Nucleic Acids Res Y1 - 2006 A1 - Flockhart, Ian A1 - Booker, Matthew A1 - Kiger, Amy A1 - Boutros, Michael A1 - Armknecht, Susan A1 - Ramadan, Nadire A1 - Richardson, Kris A1 - Xu, Andrew A1 - Perrimon, Norbert A1 - Mathey-Prevot, Bernard KW - Animals KW - Computational Biology KW - Databases, Genetic KW - Drosophila KW - Gene Library KW - Genome, Insect KW - Internet KW - RNA Interference KW - RNA, Double-Stranded KW - Software KW - User-Computer Interface AB -

RNA interference (RNAi) has become a powerful tool for genetic screening in Drosophila. At the Drosophila RNAi Screening Center (DRSC), we are using a library of over 21,000 double-stranded RNAs targeting known and predicted genes in Drosophila. This library is available for the use of visiting scientists wishing to perform full-genome RNAi screens. The data generated from these screens are collected in the DRSC database (http://flyRNAi.org/cgi-bin/RNAi_screens.pl) in a flexible format for the convenience of the scientist and for archiving data. The long-term goal of this database is to provide annotations for as many of the uncharacterized genes in Drosophila as possible. Data from published screens are available to the public through a highly configurable interface that allows detailed examination of the data and provides access to a number of other databases and bioinformatics tools.

VL - 34 IS - Database issue U1 - http://www.ncbi.nlm.nih.gov/pubmed/16381918?dopt=Abstract ER -