@article {825761,
	title = {A regulatory network of Drosophila germline stem cell self-renewal.},
	journal = {Dev Cell},
	volume = {28},
	year = {2014},
	month = {2014 Feb 24},
	pages = {459-73},
	abstract = {<p>Stem cells possess the capacity to generate two cells of distinct fate upon division: one cell retaining stem cell identity and the other cell destined to differentiate. These cell fates are established by cell-type-specific genetic networks. To comprehensively identify components of these networks, we performed a large-scale RNAi screen in Drosophila female germline stem cells (GSCs) covering \~{}25\% of the genome. The screen identified 366 genes that affect GSC maintenance, differentiation, or other processes involved in oogenesis. Comparison of GSC regulators with neural stem cell self-renewal factors identifies common and cell-type-specific self-renewal genes. Importantly, we identify the histone methyltransferase Set1 as a GSC-specific self-renewal factor. Loss of Set1 in neural stem cells does not affect cell fate decisions, suggesting a differential requirement of H3K4me3 in different stem cell lineages. Altogether, our study provides a resource that will help to further dissect the networks underlying stem cell self-renewal.</p>},
	keywords = {Animals, Cell Differentiation, Cell Division, Cell Lineage, drosophila melanogaster, Drosophila Proteins, Female, Germ Cells, Ovary, RNA Interference, Signal Transduction, Stem Cells},
	issn = {1878-1551},
	doi = {10.1016/j.devcel.2014.01.020},
	author = {Yan, Dong and Neum{\"u}ller, Ralph A and Buckner, Michael and Ayers, Kathleen and Li, Hua and Hu, Yanhui and Yang-Zhou, Donghui and Pan, Lei and Wang, Xiaoxi and Kelley, Colleen and Vinayagam, Arunachalam and Binari, Richard and Randklev, Sakara and Perkins, Lizabeth A and Xie, Ting and Cooley, Lynn and Perrimon, Norbert}
}
