@article {825426,
	title = {ESCRT factors restrict mycobacterial growth.},
	journal = {Proc Natl Acad Sci U S A},
	volume = {105},
	year = {2008},
	month = {2008 Feb 26},
	pages = {3070-5},
	abstract = {<p>Nearly 1.7 billion people are infected with Mycobacterium tuberculosis. Its ability to survive intracellularly is thought to be central to its success as a pathogen, but how it does this is poorly understood. Using a Drosophila model of infection, we identify three host cell activities, Rab7, CG8743, and the ESCRT machinery, that modulate the mycobacterial phagosome. In the absence of these factors the cell no longer restricts growth of the non-pathogen Mycobacterium smegmatis. Hence, we identify factors that represent unique vulnerabilities of the host cell, because manipulation of any one of them alone is sufficient to allow a nonpathogenic mycobacterial species to proliferate. Furthermore, we demonstrate that, in mammalian cells, the ESCRT machinery plays a conserved role in restricting bacterial growth.</p>},
	keywords = {Animals, Cell Line, DNA-Binding Proteins, Drosophila, Endosomal Sorting Complexes Required for Transport, Endosomes, Microscopy, Fluorescence, Multiprotein Complexes, Mycobacterium, Mycobacterium Infections, rab GTP-Binding Proteins, RNA Interference, Species Specificity, Transcription Factors, Vesicular Transport Proteins, Virulence},
	issn = {1091-6490},
	doi = {10.1073/pnas.0707206105},
	author = {Philips, Jennifer A and Porto, Maura C and Wang, Hui and Rubin, Eric J and Perrimon, Norbert}
}
