@article {1070971, title = {Accessing the Phenotype Gap: Enabling Systematic Investigation of Paralog Functional Complexity with CRISPR}, journal = {Dev Cell}, volume = {43}, year = {2017}, month = {2017 Oct 09}, pages = {6-9}, abstract = {Single-gene knockout experiments can fail to reveal function in the context of redundancy, which is frequently observed among duplicated genes (paralogs) with overlapping functions. We discuss the complexity associated with studying paralogs and outline how recent advances in CRISPR will help address the "phenotype gap" and impact biomedical research.}, issn = {1878-1551}, doi = {10.1016/j.devcel.2017.09.020}, author = {Ewen-Campen, Ben and Mohr, Stephanie E and Hu, Yanhui and Perrimon, Norbert} }