#  "One vs. All" a new feature in our ortholog search tool 

 





October 03, 2016

 

 

Our DIOPT ortholog search tool has been updated to include the option to search for orthologs of a gene in all other species included. So you can search with, for example, a fly gene, and see orthologs in human, mouse, rat, frog, worm, and yeast.

Click on the button "show summary of top scores" to see a heat map view of the top-scoring ortholog matches in other species to your query species. This feature helps you see quickly if a gene has been conserved across many species or is, for example, only found in vertebrates.

As always, our tool supports batch-mode searches (you can enter more than one gene at a time) and allows you to download results as a file.

Feedback on DIOPT and our [other online tools](/tools) is welcome.

[Click here](http://www.flyrnai.org/diopt) for a direct link to the DIOPT ortholog search tool.

 ![DIOPT home page showing the ALL species search option](/sites/g/files/omnuum5366/files/fly/files/screen_shot_2016-10-03_at_1.02.07_pm.png)

 

 ![search results with ALL option (input gene is hedgehog or hh)](/sites/g/files/omnuum5366/files/fly/files/diopt-all-with-top-button.jpg)

 

Results of an "all" search with *Drosophila* hh, wg, Atg1, and p53, followed by a click to view the "Summary of Best Scores" heatmap:

 ![Summary of Best Scores following a search with fly hh, wg, Atg1, and p53 genes](/sites/g/files/omnuum5366/files/fly/files/hh-wg-atg1-p53-all-heatmap.jpg)

 

And from a best ortholog summary table, you can further link to a view of the domains present in each ortholog and multi-sequence alignment (see here for Hh orthologs). We are working on further improvements and welcome your feedback.

 ![Multi sequence alignments for ALL search best matches](/sites/g/files/omnuum5366/files/fly/files/multi-seq-align-hh.png)

 



 

 

 

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 Attachments- [  image  multi-seq-align-hh.png ](/sites/g/files/omnuum5366/files/fly/files/multi-seq-align-hh.png)
 
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 See also:- [ C. elegans (worm) ](/organism/c-elegans-worm)
- [ Drosophila (fly) ](/organism/drosophila-fly)
- [ Human ](/organism/human)
- [ Mouse ](/organism/mouse)
- [ Rat ](/organism/rat)
- [ Xenopus (frog) ](/organism/xenopus-frog)
- [ Yeast (S. cerevisiae) ](/organism/yeast-s-cerevisiae)
- [ Yeast (S. pombe) ](/organism/yeast-s-pombe)
- [ Zebrafish ](/organism/zebrafish)
- [ Data mining ](/topics/data-mining)
- [ Ortholog identification ](/topics/ortholog-identification)
 
 

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