#  HuDis-TRiP RNAi fly stocks 

 



 ##  

  expand\_more  

 
  

 

*Drosophila* is proven model system for the study of human diseases. To facilitate modeling of human diseases in the fly, the Human Disease TRiP (HuDis-TRiP) generated RNAi fly stocks targeting high-confidence fly orthologs of human disease-associated genes.

- the collection includes 92% coverage of 670 highest-confidence fly orthologs of highest-confidence disease-associated human genes
- a total of more than 2,000 fly stocks targeting high-confidence fly orthologs of disease-associated human genes have been generated

Below we provide a list of high-confidence human gene-fly ortholog pairs for which there is also high-confidence evidence that the human gene is implicated in disease.

- view [**a list of fly stocks in HuDis-TRiP fly collection**](http://www.flyrnai.org/HuDis-TRiP), including stock IDs
- click [**here**](/file_url/191) to download list in .XLS format.
- the disease gene relationships are from the [NCBI Online Mendelian Inheritance in Man database](http://www.ncbi.nlm.nih.gov/omim).
- the ortholog relationships are based on [DIOPT](/diopt) scores (scores of 8, 9 or 10; see [Hu et al. 2011 BMC Bioinformatics](http://www.flyrnai.org/supplement/DIOPT-BMC_bioinformatics.pdf) and [flyrnai.org/DIOPT](http://www.flyrnai.org/diopt)).
- please note that you can find more putative fly ortholog genes (DIOPT scores of 1 or more) searching with the same disease term at [DIOPT-DIST](http://flyrnai.org/DIOPT-DIST). The HuDis list is meant as a high-confidence starting off point. It is not a comprehensive list of fly gene-human disease gene relationships.
- all of these genes have been nominated for TRiP VALIUM20 fly stock production so more lines should be available for these genes in the future. See [here](/knockdown-vectors) for further information on VALIUM vectors.
- we have made note below of what VALIUM20 construct RNAi fly stocks are currently available.
- this is not a comprehensive list of all TRiP or all fly RNAi lines available, as other TRiP stocks (e.g. [VALIUM22](http://www.flyrnai.org/TRiP-REA.html)) and other collections (e.g. [NIG-Japan](http://www.shigen.nig.ac.jp/fly/nigfly/about/aboutRnai.jsp) and [VDRC](http://stockcenter.vdrc.at/control/main)) are also available for some of these genes. You can use [UP-TORR](http://www.flyrnai.org/up-torr) to search all three collections.

  
We gratefully acknowledge support from ORIP/NCRR R24 RR032668 to N. Perrimon