# Disease-related studies in the fly model If the goal is human disease-related studies, why do functional genomics in *Drosophila*? ## Flies provide - a simple, low-redundancy, well-annotated genome - all major signaling pathways conserved (Hh, Toll, Hippo, etc.) - best understood model of insect vectors of diseases (e.g. mosquitoes) and insect pests - proven model of human diseases including cancer, heart disease, obesity and diabetes, neurodegenerative diseases, congenital disorders, kidney stones, neuronal injury, behavioral disorders, and more Many researchers use our technologies to to uncover new findings relevant to disease and potential drug targets. We welcome inquiries from non-*Drosophila* researchers looking to connect with specific expertise and resources. We also recommend our [fly models of human diseases blog](http://flydiseasemodels.blogspot.com/). Our [HuDis-TRiP fly stocks page](http://www.flyrnai.org/HuDis-TRiP) lists RNAi fly stocks targeting fly orthologs of human disease-associated genes. Learn more about the HuDis-TRiP project [at this page](/hudis-trip-fly-stocks). See links below to relevant online tools, reagents, publications, and more. ## Online tools [### DIOPT-DIST ](/diopt-dist) DIOPT-Diseases and Traits takes our DIOPT approach to ortholog mapping a step further. At DIOPT-DIST, model organism genes are mapped to putative orthologs in the human genome, and human genes are associated with disease-gene information. You can start... description [### Gene2Function ](/G2F) Gene2Function (G2F) G2F lets you view summary information for all orthologs of a given gene in common model species. This information can help you quickly gain a sense of how well-studied the gene is in a given system and learn about function. URL http:/... description ## Reagents [### HuDis-TRiP RNAi fly stocks ](/hudis-trip-fly-stocks) Drosophila is proven model system for the study of human diseases. To facilitate modeling of human diseases in the fly, the Human Disease TRiP (HuDis-TRiP) generated RNAi fly stocks targeting high-confidence fly orthologs of human disease-associated genes... description ## News [### DRSC/TRiP and DRSC-BTRR Office Hours ](/OfficeHours2021) September 13, 2021 New this fall: Online office hours! Do you have questions about modifying Drosophila cell lines with CRISPR or performing large-scale cell screens? Questions about in vivo RNAi with TRiP fly stocks or CRISPR knockout or activation with our sgRNA fly... ![Graphical image of tissue culture, fly pushing, and computer, and the team of people who work with them](/sites/g/files/omnuum5366/files/styles/hwp_16_9__480x270/public/fly/files/team.jpeg?itok=NLIA2Ora) [### New publications from the DRSC bioinformatics team ](/news/new-publications-drsc-bioinformatics-team) October 28, 2020 The DRSC bioinformatics team, led by Dr. Claire Yanhui Hu, has recently published two new papers. One reports development of BioLitMine, an advanced literature mining resource. The other provides an overview of our online resources, which can be grouped... ![Screenshot image of our Online Tools Overview page](/sites/g/files/omnuum5366/files/styles/hwp_16_9__480x270/public/fly/files/grid_fgr-home.png?itok=RYdQnNRO) [### DRSC-Biomedical Technology Research Resource ](/news/drsc-biomedical-technology-research-resource) October 21, 2019 We are pleased to announce that we have been funded by NIH NIGMS to form the Drosophila Research & Screening Center-Biomedical Technology Research Resource (DRSC-BTRR). The P41-funded DRSC-BTRR (N. Perrimon, PI; S. Mohr, Co-I) builds upon and extends past... ![Graphical image of tissue culture, fly pushing, and computer, and the team of people who work with them](/sites/g/files/omnuum5366/files/styles/hwp_16_9__480x270/public/fly/files/team.jpeg?itok=NLIA2Ora) [### Drosophila cell screen with DRSC reagent library contributes to identification of new therapeutic target for renal cancer ](/news/drsc-libraries-contribute-identification-new-therapeutic-target-renal-cancer) October 07, 2019 We here at the DRSC/TRiP are thrilled to see this study from Hilary Nicholson et al. published in Science Signaling. The study provides a great example of how screens in Drosophila cultured cells can be used as part of a cross-species platform aimed at... ![Photo of 384-well assay plates](/sites/g/files/omnuum5366/files/styles/hwp_16_9__480x270/public/fly/files/img_7618.jpg?itok=FtUW2sKO) [### DRSC Bioinformatics launches iProteinDB and BioLitMine ](/news/drsc-bioinformatics-launches-iproteindb-and-biolitmine) August 29, 2018 We have two new online tools available: iProteinDB and BioLitMine. Both continue our series of resources aimed at integrating existing information in new ways to facilitate data mining and development of new hypotheses. In addition, iProteinDB includes a... ![Screenshot of a results page from iProteinDB](/sites/g/files/omnuum5366/files/styles/hwp_16_9__480x270/public/fly/files/iproteindb_proteindetails_screenshot.jpg?itok=f05ihQJc) [### Community Building and Online Resources at the DRSC/TRiP ](/news/community-building-and-online-resources-drsctrip) August 14, 2018 At the DRSC/TRiP-Functional Genomics Resources, we are interested to let the community know about new resources we have built. We are also interested more broadly to help connect community members to additional resources that could help their research... ![screenshot of the drosophilaresearch.org news page](/sites/g/files/omnuum5366/files/styles/hwp_16_9__480x270/public/fly/files/dr_news_screenshot_20180814.jpg?itok=lygmOHRE) ## Contact Us Please [contact us](/contact) for any questions. ## Publications Download 6 citations download- [BibTeX](/bibcite/export?pager_style=no_pager&number_of_items=6&sort_field=bibcite_year--desc&taxonomy_filters%5Bfield_hwp_c_topics12%5D%5B0%5D%5Btarget_id%5D=114191&&&format=bibtex) - [EndNote X3 XML](/bibcite/export?pager_style=no_pager&number_of_items=6&sort_field=bibcite_year--desc&taxonomy_filters%5Bfield_hwp_c_topics12%5D%5B0%5D%5Btarget_id%5D=114191&&&format=endnote8) - [EndNote 7 XML](/bibcite/export?pager_style=no_pager&number_of_items=6&sort_field=bibcite_year--desc&taxonomy_filters%5Bfield_hwp_c_topics12%5D%5B0%5D%5Btarget_id%5D=114191&&&format=endnote7) - [Endnote tagged](/bibcite/export?pager_style=no_pager&number_of_items=6&sort_field=bibcite_year--desc&taxonomy_filters%5Bfield_hwp_c_topics12%5D%5B0%5D%5Btarget_id%5D=114191&&&format=tagged) - [Marc](/bibcite/export?pager_style=no_pager&number_of_items=6&sort_field=bibcite_year--desc&taxonomy_filters%5Bfield_hwp_c_topics12%5D%5B0%5D%5Btarget_id%5D=114191&&&format=marc) - [PubMedId](/bibcite/export?pager_style=no_pager&number_of_items=6&sort_field=bibcite_year--desc&taxonomy_filters%5Bfield_hwp_c_topics12%5D%5B0%5D%5Btarget_id%5D=114191&&&format=pubmed_id) - [RIS](/bibcite/export?pager_style=no_pager&number_of_items=6&sort_field=bibcite_year--desc&taxonomy_filters%5Bfield_hwp_c_topics12%5D%5B0%5D%5Btarget_id%5D=114191&&&format=ris) ### 2021 Raghuvir Viswanatha, Enzo Mameli, Jonathan Rodiger, Pierre Merckaert, Fabiana Feitosa-Suntheimer, Tonya Colpitts, Stephanie Mohr, Yanhui Hu, and Norbert Perrimon. 2021. “[Bioinformatic and Cell-Based Tools for Pooled CRISPR Knockout Screening in Mosquitos](/publications/bioinformatic-and-cell-based-tools-pooled-crispr-knockout-screening-mosquitos-0)”. Nat Commun, 12, 1, Pp. 6825. doi:10.1038/s41467-021-27129-3 Raghuvir Viswanatha, Enzo Mameli, Jonathan Rodiger, Pierre Merckaert, Fabiana Feitosa-Suntheimer, Tonya Colpitts, Stephanie Mohr, Yanhui Hu, and Norbert Perrimon. 2021. “[Bioinformatic and Cell-Based Tools for Pooled CRISPR Knockout Screening in Mosquitos](/publications/bioinformatic-and-cell-based-tools-pooled-crispr-knockout-screening-mosquitos-0)”. Nat Commun, 12, 1, Pp. 6825. doi:10.1038/s41467-021-27129-3 - add\_circle do\_not\_disturb\_on Abstract - [ picture\_as\_pdfs41467-021-27129-31.pdf](/sites/g/files/omnuum5366/files/fly/files/s41467-021-27129-31.pdf) Mosquito-borne diseases present a worldwide public health burden. Current efforts to understand and counteract them have been aided by the use of cultured mosquito cells. Moreover, application in mammalian cells of forward genetic approaches such as... - [ picture\_as\_pdfs41467-021-27129-31.pdf](/sites/g/files/omnuum5366/files/fly/files/s41467-021-27129-31.pdf) Hans M. Dalton, Raghuvir Viswanatha, Ricky Brathwaite Jr., Jae Sophia Zuno, Stephanie Mohr, Norbert Perrimon, and Clement Y. Chow. 2021. “[A Genome-Wide CRISPR Screen Identifies the Glycosylation Enzyme DPM1 As a Modifier of DPAGT1 Deficiency and ER Stress](/publications/genome-wide-crispr-screen-identifies-glycosylation-enzyme-dpm1-modifier-dpagt1)”. BioRxiv Hans M. Dalton, Raghuvir Viswanatha, Ricky Brathwaite Jr., Jae Sophia Zuno, Stephanie Mohr, Norbert Perrimon, and Clement Y. Chow. 2021. “[A Genome-Wide CRISPR Screen Identifies the Glycosylation Enzyme DPM1 As a Modifier of DPAGT1 Deficiency and ER Stress](/publications/genome-wide-crispr-screen-identifies-glycosylation-enzyme-dpm1-modifier-dpagt1)”. BioRxiv - add\_circle do\_not\_disturb\_on Abstract - [ descriptionPublisher's Version](https://www.biorxiv.org/content/10.1101/2021.12.03.471178v1) - [ picture\_as\_pdf2021.12.03.471178v1.full\_...](/sites/g/files/omnuum5366/files/fly/files/2021.12.03.471178v1.full_.pdf) Partial loss-of-function mutations in glycosylation pathways underlie a set of rare diseases called Congenital Disorders of Glycosylation (CDGs). In particular, DPAGT1 CDG is caused by mutations in the gene encoding the first step in N-glycosylation... - [ descriptionPublisher's Version](https://www.biorxiv.org/content/10.1101/2021.12.03.471178v1) - [ picture\_as\_pdf2021.12.03.471178v1.full\_...](/sites/g/files/omnuum5366/files/fly/files/2021.12.03.471178v1.full_.pdf) ### 2020 Yanhui Hu, Verena Chung, Aram Comjean, Jonathan Rodiger, Fnu Nipun, Norbert Perrimon, and Stephanie Mohr. 2020. “[BioLitMine: Advanced Mining of Biomedical and Biological Literature About Human Genes and Genes from Major Model Organisms](/publications/biolitmine-advanced-mining-biomedical-and-biological-literature-about-human-genes)”. G3 (Bethesda). doi:10.1534/g3.120.401775 Yanhui Hu, Verena Chung, Aram Comjean, Jonathan Rodiger, Fnu Nipun, Norbert Perrimon, and Stephanie Mohr. 2020. “[BioLitMine: Advanced Mining of Biomedical and Biological Literature About Human Genes and Genes from Major Model Organisms](/publications/biolitmine-advanced-mining-biomedical-and-biological-literature-about-human-genes)”. G3 (Bethesda). doi:10.1534/g3.120.401775 - add\_circle do\_not\_disturb\_on Abstract - [ picture\_as\_pdf4531.full\_.pdf](/sites/g/files/omnuum5366/files/fly/files/4531.full_.pdf) The accumulation of biological and biomedical literature outpaces the ability of most researchers and clinicians to stay abreast of their own immediate fields, let alone a broader range of topics. Although available search tools support identification of... - [ picture\_as\_pdf4531.full\_.pdf](/sites/g/files/omnuum5366/files/fly/files/4531.full_.pdf) Yanhui Hu, Aram Comjean, Jonathan Rodiger, Yifang Liu, Yue Gao, Verena Chung, Jonathan Zirin, Norbert Perrimon, and Stephanie Mohr. 2020. “[FlyRNAi.Org-the Database of the Drosophila RNAi Screening Center and Transgenic RNAi Project: 2021 Update](/publications/flyrnaiorg-database-drosophila-rnai-screening-center-and-transgenic-rnai-project)”. Nucleic Acids Res. doi:10.1093/nar/gkaa936 Yanhui Hu, Aram Comjean, Jonathan Rodiger, Yifang Liu, Yue Gao, Verena Chung, Jonathan Zirin, Norbert Perrimon, and Stephanie Mohr. 2020. “[FlyRNAi.Org-the Database of the Drosophila RNAi Screening Center and Transgenic RNAi Project: 2021 Update](/publications/flyrnaiorg-database-drosophila-rnai-screening-center-and-transgenic-rnai-project)”. Nucleic Acids Res. doi:10.1093/nar/gkaa936 - add\_circle do\_not\_disturb\_on Abstract - [ picture\_as\_pdfgkaa936.pdf](/sites/g/files/omnuum5366/files/fly/files/gkaa936.pdf) The FlyRNAi database at the Drosophila RNAi Screening Center and Transgenic RNAi Project (DRSC/TRiP) provides a suite of online resources that facilitate functional genomics studies with a special emphasis on Drosophila melanogaster. Currently, the... - [ picture\_as\_pdfgkaa936.pdf](/sites/g/files/omnuum5366/files/fly/files/gkaa936.pdf) ### 2019 Andrey Parkhitko, Patrick Jouandin, Stephanie Mohr, and Norbert Perrimon. 2019. “[Methionine Metabolism and Methyltransferases in the Regulation of Aging and Lifespan Extension across Species](/publications/methionine-metabolism-and-methyltransferases-regulation-aging-and-lifespan)”. Aging Cell, Pp. e13034. doi:10.1111/acel.13034 Andrey Parkhitko, Patrick Jouandin, Stephanie Mohr, and Norbert Perrimon. 2019. “[Methionine Metabolism and Methyltransferases in the Regulation of Aging and Lifespan Extension across Species](/publications/methionine-metabolism-and-methyltransferases-regulation-aging-and-lifespan)”. Aging Cell, Pp. e13034. doi:10.1111/acel.13034 - add\_circle do\_not\_disturb\_on Abstract Methionine restriction (MetR) extends lifespan across different species and exerts beneficial effects on metabolic health and inflammatory responses. In contrast, certain cancer cells exhibit methionine auxotrophy that can be exploited for therapeutic... Stephanie E. Mohr and Norbert Perrimon. 2019. “[Drosophila Melanogaster: A Simple System for Understanding Complexity.](/publications/drosophila-melanogaster-simple-system-understanding-complexity)”. Dis Model Mech, 12, 10 Stephanie E. Mohr and Norbert Perrimon. 2019. “[Drosophila Melanogaster: A Simple System for Understanding Complexity.](/publications/drosophila-melanogaster-simple-system-understanding-complexity)”. Dis Model Mech, 12, 10 - add\_circle do\_not\_disturb\_on Abstract - [ descriptionPublisher's Version](https://dmm.biologists.org/content/12/10/dmm041871.long) - [ picture\_as\_pdf2019\_DMM\_Mohr.pdf](/sites/g/files/omnuum5366/files/fly/files/2019_DMM_Mohr.pdf) Understanding human gene function is fundamental to understanding and treating diseases. Research using the model organism *Drosophila melanogaster* benefits from a wealth of molecular genetic resources and information useful for efficient *in* *vivo* experimen... - [ descriptionPublisher's Version](https://dmm.biologists.org/content/12/10/dmm041871.long) - [ picture\_as\_pdf2019\_DMM\_Mohr.pdf](/sites/g/files/omnuum5366/files/fly/files/2019_DMM_Mohr.pdf) [ More arrow\_circle\_right ](/publications/topics/disease-related-studies)